Endocrine Abstracts

Pancreatic beta cell senescence is one of the recent explanations for theincreased prevalence of type 2 diabetes in the elderly. Aging may exert a distinct influence on pancreatic β cell turnover, regeneration capacity and function. Oxidative stresses induced by metabolic stresses reduce pancreatic beta cell mass and secretion. We investigated how metabolic stresses effect on pancreatic beta cell senescence. INS-1 cells were exposed to 33mM glucose (glucotoxicity: high gl...

Beta cell senescence is being regarded as the one of the mechanisms of beta cell dysfunction. Melatonin secreted primarily from the pineal glandregulates a variety of physiological functions, such as sleep, circadian rhythms, and neuroendocrine actions. Melatonin has also very strong anti-oxidant effects. The effects of melatonin on the pancreatic beta cell senescence induced by glucolipotoxicity have not been studied. INS-1 cells were exposed to 33mM glucose with palmitate 20...